HONEY IN MEDICAL TREATMENT

Honey contains lots of medical abilities. Now a days hospital acquired infections and treatment related wound complications constitute a tremendous burden for the health care system, particularly given the serious increase in multidrug resistant pathogens. Imagine that the large part of nosocomial infections can be prevented using a simple treatment. In this respect, honey is used mainly in topical cutaneous wound care because of its potent board spectrum antibacterial and wound healing activities. However therapeutic use outside this scope has been limited. The current revise provides an in depth view of studies using honey outside the conventional wound care indications. Non-conventional routes of honey application include subcutaneous, intra socket, abdominal, and oral administration in novel indication, such as post colon surgery, mucositis, and tooth extraction. Honey consistently demonstrates beneficial therapeutic activities in these novel applications, orchestrating, antimicrobial and prophylactic activity, reducing inflammation and wound dehiscence, and inducing healing, epithelialization, and analgesic activity. Several molecular mechanisms are responsible for those beneficial clinic effects of honey during the course of wound healing. Inflammatory effects of honey, such as indication of INOS, IL-LB, and COX-2, are mediated by TLR4 signating. In contrast honey's anti inflammatory action and antioxidant pathways by inducing NRF2 target genes, inducing HO-1, and PRDX1. The molecular and biochemical pathways activated by honey during the different phase of wound healing. Honey is a valuable alternative to conventional antimicrobial and anti inflammatory therapies that can strongly reduce nosocomial infection